Haemostasis

Haemostasis

The hemostasis system is a biological system in the body, the function of which is to preserve the liquid state of the blood, to stop bleeding when the walls of blood vessels are damaged and to dissolve blood clots that have performed their function. The process of hemostasisis carefully balanced, so that the bleeding quickly stops and there is no thrombosis that does not correspond to the physiological need. The reason of the failure of hemostatic phenomena are numerous diseases, so you need to know the standardized approaches to the clinical and laboratory diagnosis of any disorders of hemostasis.

The value of the hemostatic system is much more complicated and wider. Hemostasis factors are involved in the preservation of the liquid state of the blood, regulation of transcapillary metabolism, resistance of the vascular wall, affect the intensity of reparative processes, etc. There are two main mechanisms to stop bleeding when the vessels are damaged, which mainly depend on the states:

1.     Primary or vascular platelet hemostasis due to vasospasm and their mechanical blockage with platelet aggregates. When damage to the vessel wall of collagen molecules is revealed, adhesion (adhesion), activation and aggregation (gluing together) of platelets occurs. Those. This image should be called “white thrombus”, i.e. thrombus with a predominance of platelets.

2.      Secondary, or coagulative hemostasis (blood coagulation), is triggered by a tissue factor affecting the surrounding damaged vessels tissue, and regulated by numerous blood coagulation factors. He is the so-called "red thrombus", because the resulting fibrin mesh includes red blood cell cells.

As a result, finally, the convolutional system of blood will be performed. This is platelet-fibrin process. The final stage of the hemostasis system is fibrinolysis. The fibrinolysis system destroys the fibrin vessel as the damaged vessel is repaired, and the need for it is gone.

 

 

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